看见一个 Expert Review of Anticancer Therapy。你们前面用依维莫斯,血、肝肾功能还好。下一步是否考虑索拉非尼+依维莫斯。供你参考。+ @2 c7 {2 q% a# |0 {2 T6 G! ^
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Currently available feasibility data for possible combination strategies. - k0 n, p8 ?! @4 W5 E
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Combination Feasibility according to preliminary data ' Z v7 [/ N2 @4 P& d4 B& m" E
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Bevacizumab + sorafenib Yes, reduced dose 3 I, t8 X( N' r, M4 ^
Bevacizumab + sunitinib† No 1 W8 {! G" V7 v5 ^8 S0 \
Bevacizumab + temsirolimus Yes
3 L/ `/ {6 g% U2 ^Bevacizumab + everolimus Yes 6 W& h7 J% M+ s. t7 U
Sorafenib + sunitinib ?
7 J+ |5 [3 c+ W qSorafenib + temsirolimus Yes, reduced dose
0 C0 I" y2 ?- c& I [; S7 L! I. D5 lSorafenib + everolimus Yes, reduced dose - ]" U1 H- F: v
Sunitinib + temsirolimus† No ( j" V( v2 I2 K
Sunitinib + everolimus ? & K, u( b4 c* c* e& G/ ]: b# L9 K- y
Temsirolimus + everolimus ?
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& Y8 O# z, ]4 g }+ F+ _†Led to US FDA warning.- [! k+ H P+ n/ h/ P' ?+ v- K
?: As yet unattempted combination.$ `2 O7 y, e/ g3 p
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